We are seeking a highly motivated and detail-oriented Process Development Associate to support laboratory-scale synthesis and downstream processing of oligonucleotide-based drug substances. This hands-on role involves chemical synthesis, purification, and analytical testing, contributing to process optimization and technical support for contract manufacturing activities.
Key Responsibilities
- Perform chemical synthesis of oligonucleotides at scales up to 11 mmol.
- Execute downstream processing steps including preparative HPLC, ultrafiltration, annealing, concentration, and lyophilization.
- Conduct in-process analytical testing using techniques such as AX-HPLC, IPRP-HPLC, LC-MS, and UV-Vis spectroscopy.
- Provide technical input for the optimization of contract manufacturing processes.
- Support method development and troubleshooting for oligonucleotide purification and analysis.
- Maintain accurate and thorough laboratory records in accordance with good documentation practices.
- Ensure compliance with safety protocols and contribute to routine lab and equipment maintenance.
- Uphold high standards of scientific integrity and laboratory cleanliness.
- Work effectively within cross-functional teams in a fast-paced, deadline-driven environment.
- Communicate findings and progress clearly to team members and stakeholders.
Requirements
- Bachelor’s degree in Chemistry or related field.
- Minimum of 3 years of laboratory experience, preferably in an industrial or GMP setting.
- Basic understanding of analytical techniques including pH, osmolality, conductivity, HPLC, and LC-MS.
- Hands-on experience with oligonucleotide synthesis and downstream processing is highly desirable.
- Familiarity with phosphoramidite chemistry, chromatography, and ultrafiltration is a plus.
- Strong attention to detail and commitment to scientific rigor.
- Excellent documentation and organizational skills.
- Ability to maintain a safe and orderly lab environment.
- Effective communication and teamwork skills.
- Proactive, responsible, and adaptable to dynamic project timelines.
Benefits
- Contract, with possible extension through end of 2025.